Study on PTEN and CD44v6 Genes as ... - Cancer Research Center

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[Abstract]

Objective: To study the expression of PTEN and CD44V6 protein in the rectal cancer, and the distance of mucosa adjacent to the rectal cancer. To discuss the relationship of the expression of PTEN and CD44V6 between the rectal cancer tissue and the mucosa adjacent to the cancer, major clinicopathological features was discuss too. This study was probe into PTEN and CD44v6 protein protect anus among the skill as cut reason predict value of factor far in carcinoma of the rectum..Methods: To examine the expression of PTEN and CD44V6 protein in the body of the rectal cancer , the mucosa adjacent to the cancer and normal colorectal mucosa. The relationship between the expression and the change of mucin. The immunohistochemical research help finish the study, and the samples came from the 28 patients who had got dissection for rectal cancer.The transitional mucosa adjacent to rectal cancer(1cm?3cm?5cm group) was the film dyed. Microscopic distal intramural expression was examined by PTEN/CD44V6-immunohistochemistry, HID-AB film dyeing,comparing with conventional hematoxylineosin staining in consecutive slice. Resulst:?The positive expression of PTEN protein were 39.29%(11/28),39.29%(11/28),42.86%(12/28) ,89.29%(25/28) ,78.57%(22/28) in colorectal cancer,transitional mucosa adjacent to rectal cancer(1cm?3cm?5cm group) and normal colorectal mucosa respectively. Dealt with by statistics, the expressing rate in the former three are organized of PTEN protein, there is no significance difference (P> 0.05 ), in the 5cm group transitional mucosa adjacent to rectal cancer and normal colorectal mucosa group is no significance difference (P> 0.05 ) ,too. but The expression of PTEN protein in colorectal cancer and transitional mucosa adjacent to rectal cancer(1cm?3cm group) is significantly higher than that in normal colorectal mucosa?5cm group transitional mucosa adjacent to rectal cancer group (P 0.05 ), in the 5cm group transitional mucosa adjacent to rectal cancer and normal colorectal mucosa group is no significance difference (P> 0.05 ) ,too. but The expression of CD44V6 protein in colorectal cancer and transitional mucosa adjacent to rectal cancer(1cm?3cm group) is significantly higher than that in normal colorectal mucosa?5cm group transitional mucosa adjacent to rectal cancer group (P

Title: Study on PTEN and CD44v6 Genes as Prognosticate Factors in the Distal Edge of Rectal Cancer Dissection in Patients with Anus-Preserving Operation

Category: Liver Cancer

Filename: Study on PTEN and CD44v6 Genes as Prognosticate Factors in the Distal Edge of Rectal Cancer Dissection in Patients with Anus-Preserving Operation.pdf

Pages: 157

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